靶点背景The 145-2C11 monoclonal antibody specifically binds to the 25-kDa ε chainof the T-cell receptor-associated CD3 complex that is expressed onthymocytes, mature T lymphocytes, and NK-T cells. The cytoplasmic domainof CD3e participates in the signal transduction events that activate severalcellular biochemical pathways as a result of antigen recognition. Soluble145-2C11 antibody can activate either unprimed (naive) or primed(memory/preactivated) T cells in vivo or in vitro, in the presence of Fcreceptor-bearing accessory cells. In contrast, plate-bound 145-2C11 canactivate T cells in the absence of accessory cells. Soluble 145-2C11antibody has been reported to induce re-directed lysis of Fc receptor-bearingtarget cells by CTL clones and can also block lysis of specific target cells byantigen-specific CTL's. Under some conditions, T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death.
推荐稀释比WB 1:500-1:2000 IHC 1:50-1:200 IF 1:100-1:500 IP 1:20
产品形式Liquid
Buffer 体系PBS with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
