Product Information： | |
Product name | KLRK1 Polyclonal Antibody |
Isotype | IgG |
Form | Lyophilized or Liquid |
Tested applications | IF,ELISA |
Species reactivity | Human |
Host Species | Rabbit |
Purity | Affinity purification |
Immunogen Information：
Immunogen | A synthetic peptide of human KLRK1 |
Calculated molecular weight | 25kDa |
Observed molecular weight | Refer to figures |
Swiss Prot | P26718 |
Gene ID (NCBI) | 22914 |
Alternative Names | CD314;D12S2489E;KLR;NKG2-D;NKG2D |
Application Notes：
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IF | 1:50 - 1:200 |
Background：
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Storage：
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Services & Support：
1. Please do not hesitate to contact us if you have any questions.
2. Please fill in the Technical Suppoprt Request Form and email the form to jiyinmei027@163.com within 3 months of receipt of the goods, and we will response to your inquiry within 24 hours.
3. The after-sale service channel will be shut down after 3 months.
