别名Axil; Axin like protein; Axin2; Axis inhibition protein 2; Conductin;
应用WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
反应物种Human,Mouse,Rat
理论分子量94kDa
表观分子量94kDa
免疫原A synthetic peptide of human Axin 2
基因ID8313
蛋白编码Q9Y2T1
宿主物种Rabbit
抗体分型IgG
纯化Affinity purification
储存Store at -20℃. Avoid freeze / thaw cycles.
靶点背景The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
