别名aPKCzeta; nPKC zeta; PKC 2; PKC ZETA; PKCZETA ; Protein kinase C zeta; r14-3-3;
应用WB;IHC
反应物种Human;Mouse;Rat
理论分子量68 kDa
表观分子量68 kDa
免疫原A synthetic phosphopeptide corresponding to residues surrounding
Ser11 of human PRKCZ
基因ID5590
蛋白编码Q05513
宿主物种Rabbit
抗体分型IgG
纯化Affinity purification
储存Store at -20℃. Avoid freeze / thaw cycles.
靶点背景Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
推荐稀释比WB 1:1000-1:2000 IHC 1:100-1:200
产品形式Liquid
Buffer 体系PBS with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
