产品名称Phospho-PKC zeta/lambda (Thr410/Thr412) Rabbit mAb
别名PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma
应用WB,IHC-P,IF-P
反应物种Human,Mouse,Rat
理论分子量76kDa
表观分子量68kDa
免疫原A synthetic phosphopeptide corresponding to residues surrounding Thr410 of human PKC zeta
基因ID5582/5584/5590
蛋白编码P05129/P41743/Q05513
宿主物种Rabbit
抗体分型IgG
纯化Affinity purification
储存Store at -20℃. Avoid freeze / thaw cycles.
靶点背景Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
推荐稀释比WB 1:2000-1:20000 IHC-P/IF-P 1:50-1:100
产品形式Liquid
Buffer 体系PBS with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
