产品名称Phospho-ErbB 2 (Tyr1248)/ErbB 4 (Tyr1284) Rabbit mAb
别名NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
应用WB,IF-ICC,FCM,IP
反应物种Human
理论分子量180kDa
表观分子量147kDa
免疫原A synthetic phosphopeptide corresponding to residues surrounding
Tyr1248 of human ErbB 2
基因ID2064
蛋白编码P04626
宿主物种Rabbit
抗体分型IgG
纯化Affinity purification
储存Store at -20℃. Avoid freeze / thaw cycles.
靶点背景This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
推荐稀释比WB 1:1000-1:5000 IF-ICC 1:100 FCM 1:20-1:50 IP 1:20-1:50
产品形式Liquid
Buffer 体系PBS with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
