别名130 kDa retinoblastoma associated protein; IB4; p130; PRB2; Rb2; Rbl2; RBR2; Retinoblastoma like 2; Retinoblastoma-related protein 2; RIC128;
应用WB,IHC-P
反应物种Human,Mouse
理论分子量130kDa
表观分子量128kDa
免疫原A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130
基因ID5934
蛋白编码Q08999
宿主物种Rabbit
抗体分型IgG
纯化Affinity purification
储存Store at -20℃. Avoid freeze / thaw cycles.
靶点背景Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
推荐稀释比WB 1:1000 IHC-P/IF-P 1:200-1:500
产品形式Liquid
Buffer 体系PBS with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
